It is hoped that with larger discovery efforts of both cannabis use54 and of cannabis use disorders, the predictive quality of PRS, not merely in terms of what they predict, but also when and how they do so, will be better elucidated. However, this study highlights that even as discovery GWAS sample sizes grow and PRS begin to attain a greater level of precision21,39, it will be of paramount importance to consider not only how genetic liability shapes health and behavior, but also the environmental context within which such behavior unfolds (e.g.,55).
