The present study exploited the tonic nature of posterior EEG alpha, and the capacity of high-resolution CSD-fPCA to identify and quantify neuronal generator patterns, to produce a promising predictor of antidepressant response. The factor score topographies suggest that a considerably smaller array of electrodes may provide a sufficient predictor, which is supported by exploratory findings (supplement S4). It is also hoped that the judicious choice of additional, phasic electrophysiologic measures (e.g., loudness dependency of auditory evoked potential; 32, 54) may provide a complementary source of information on serotonergic function to further improve outcome predictions for a range of treatments.
