A number of regions of linkage activity were found on chromosome 1 (Figure 3). The first peaked with a LOD of 2.2 at marker D1S2697 (between D1S1612 and D1S199), using the younger dataset. This peak declined as an increasing number of lighter drinkers were dropped. All linkage peaks in this region for the older dataset had a LOD of less than 1.0. Activity peaked with a LOD of 2.8 at marker GATA88F03 (between D1S491 at and D1S225), also using the younger dataset. Linkage in this region for the younger dataset increased as lighter drinkers were dropped, with the exception of the most concentrated sample of heavier drinkers, for which no linkage was observed. The older dataset also showed evidence of linkage in this region, peaking with a LOD of 2.2 at the same marker for the sample with 10% of drinkers at the low end of the consumption distribution dropped.
