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Chunk #24 — DISCUSSION

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Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.
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on increasing risk of lapse in comparison to some of the other cessation milestones. A recent study showed that bupropion was specifically effective at offsetting risk of initial lapse (62). At the same time, the fact that AGES did not predict PPA at EOT suggests that other factors are important for explaining the resumption of regular smoking behavior, which is a paramount clinical outcome in smoking cessation.