Several limitations warrant consideration to inform fine-mapping and functional characterization studies. To comprehensively evaluate the region we not only included directly genotyped SNPs, which included all SNPs known at the time of the chip development and suitable for genotyping SNPs but we also imputed to the most recent version of the 1000 Genomes Project. While this approach provides a rather complete list of variants imputed SNPs ted to be called with varying accuracy. To account for the imputation accuracy we used the dosage, which we showed results in unbiased estimates [39]. However, we also note that the overall p-value of a SNP is impacted by the imputation accuracy (lower imputation accuracy results in higher p-values). Accordingly, it is important for the interpretation of the results that not only the most significant SNPs will be considered as functional variants but also those correlated with the most significant SNPs as done in this paper. Second, for a part of the WHI samples directly genotyped SNPs were only available from a smaller subset of SNPs as genotyping in this subset was based on
