Group of the Psychiatric Genomics Consortium, 2013), genes involved in calcium channel signaling were found to be associated with ASD, ADHD, SCZ, major depressive disorder (MDD), and bipolar disorder (BIP). In follow-up work from the PGC Network and Pathways Analysis subgroup, BIP, MDD, and SCZ were collectively associated with pathways relevant to immune and neurotrophic function, histone methylation, and synaptic biology (Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium, 2015). The CDG2 project mentioned previously identified enrichment across the eight disorders for pathways relevant to glutamate receptor signaling, neurodevelopment (e.g., neuron differentiation), genes expressed during the second prenatal trimester, and voltage-gated calcium channel signaling (Lee et al., 2019). Stratified Genomic SEM is a recently introduced method that can be used to specifically examine multivariate enrichment (Grotzinger et al., 2020). Application of this method to 11 psychiatric disorders identified conserved regions to be enriched across disorders. Conserved regions capture genes that occur across species (i.e., that are conserved) and, in line with its broad transdiagnostic associations, are consequently thought to be particularly relevant to overall functioning. In contrast, GABAergic and excitatory genes were specifically enriched for shared genetic risk across BIP and SCZ. Collectively, these findings offer insight into
