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Chunk #49 — Discussion — Novelty P3 and Depression

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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In addition to the novelty vertex source, the response-related F – CP+, which corresponds to a late frontally inverting positivity, was also reduced in patients. This late source was negatively correlated with self-ratings of both depression (BDI) and physical anhedonia. It presumably reflects a response-related deficit, possibly owing to patients with melancholic or anhedonic forms of depression (see also Bruder et al., 1991).