Cnih2/3fl/fl neurons (Figure 4D). Furthermore, the difference in deactivation between GluA1A2γ-8 and GluA2A3γ-8 complexes is virtually identical to the magnitude of change in mEPSC decay in both CRE-expressing conditional GluA1 and CNIH-2/-3 (Gria1fl/fl and Cnih2/3fl/fl) KO neurons (Figure 4E). Thus, these findings indicate that the kinetic changes caused by the deletion of CNIH-2/-3 in neurons can be fully explained by the selective removal of the GluA1 subunit, leaving GluA2A3γ-8 complexes with faster kinetics.
