The common factor captures a shared genetic liability to the final seven externalizing traits (Figure 1B), and genetic variants associated with EXT predict central externalizing disorders and a range of behavioral and medical outcomes that were not in the model (see below). We performed a leave-one-phenotype-out Genomic SEM analysis to ensure that no single phenotype, e.g., the phenotype with the largest N, was unduly influencing the genetic architecture estimated for EXT (Supplementary Information section 3.5.3). We found that the genetic correlations between EXT and each of seven leave-one-phenotype-out models were not distinguishable from unity (rg ~ 0.984–0.999, SE ~ 0.028–0.035), which suggests that none of the phenotypes is driving the genetic architecture of EXT.
