location and time courses of neural generators contributing to P3 have been investigated using source reconstructions of scalp-recorded EEG, ERP recordings in patients with focal brain lesions, intracranial depth electrode recordings in humans and primates, fMRI registration during the performance of oddball tasks, and simultaneous EEG/fMRI registration (reviewed in (Linden, 2005; Polich, 2007; Soltani and Knight, 2000)) . These studies suggest that P3 generated by a distributed network of cortical regions including, most notably, the temporo-parietal junction (TPJ), medial temporal, medial frontal, and lateral prefrontal cortices, inferior parietal lobule, thalamus, as well as frontal-temporoparietal interaction and cortico-limbic interaction. Distinct processes contributing to P3 may have relatively independent genetic basis and functional significance, their associations with psychopathology need to be evaluated separately using paradigms emphasizing particular component processes (e.g. oddball or and novelty processing, visual and auditory modality), as well as advance signal analysis methods permitting the assessment of dissociable neural processes such as independent component analysis, time-frequency decomposition, connectivity measures, etc. It is possible that individual components contributing to P3 will show stronger associations with specific psychopathology phenotypes compared with the overall P3 response due to increased specificity of the neural processes represented by these components. Therefore, delineation of component
