Researchers can use our findings in two clear ways. First, to guide etiologic research to enhance the likelihood of discovering resistance factors. Second, our results can guide the modification of existing approaches to prevention and intervention research, to enhance our ability to identify factors that increase resistance to disease among apparently “at-risk” subjects. Importantly, inclusion of resistant subjects in a randomized trial will limit the apparent effectiveness of the intervention unless those resistance factors are known and properly accounted for in the design.
