Chunk #43 — Results — Utilization of chemogenetics and synthetic compounds to demonstrate drug screening capability

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Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications.

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of excitatory input via synaptic connections across the microchannels. Higher CNO concentrations also showed significant differences compared to vehicle and hM3Dq-negative cells in inhibitory neurons (Fig. 7C and D). This experiment indicates that functionality of neurons within a defined neurocircuitry can be assayed in a high-throughput manner using our platform.