these two SNPs and levels of CPD (Pinteraction=0.94 and Pinteraction=0.88 for rs4105144 and rs7937, respectively) and cotinine (Pinteraction=0.90 and Pinteraction=0.20 for rs4105144 and rs7937, respectively) was detected in smokers in the present study. Among current smokers adjustment for as-measured cotinine led to attenuations of estimated effects by 44% for rs16969968 and 18% for rs578776; adjustment for regression-dilution bias corrected cotinine led to further attenuation of the estimated effect of the 15q25 locus (OR=1.06 95%CI 0.77-1.46 and OR=0.84 95%CI 0.6-1.18). Inversely, adjustment for cotinine and regression-dilution bias corrected cotinine enhanced the apparent effect of 19q13 SNPs (Table 4).
