membership scores as a quantitative trait, we searched for neighboring SNPs that are correlated with these module membership scores (Fig. 6H), which we call module-switching QTLs (modQTLs). Searching a window of 1Mbp around each gene in cis, we found a total of 2102 modQTLs associated with statistically significant switching (FDR < 0.05) between dissimilar gene modules (correlation distance > 0.5), suggesting that genetic variation for those genes leads to changes in multitissue regulatory programs. For example, the ZFP57 gene shows three distinct patterns of multitissue expression across individuals, and three nearby SNPs are associated with these changes, suggesting a genetic basis for these multitissue differences (Fig. 6H).
