Chunk #30 — Results

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Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.

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Figure 3 shows the plots of –log10(p values) by chromosomal location for the analysis of all stroke and the three main subtypes.Table 3Association signals for SNPs selecting for testing in the independent replication cohort by subtypeChrSNPCandidate geneRARAFpdiscovery; ORdiscovery(95% CI)All replication samplesReplication in European descent individuals onlypreplication; ORreplication (95% CI)pcombinedpreplication; ORreplication (95% CI)pcombinedIS1rs225132ERRFI1T0·826·27×10−8; 1·12 (1·07–1·17)0·16; 0·97 (0·92–1·01)1·65×10−30·11; 0·96 (0·92–1·01)1·91×10−3IS12rs17696736NAA25 (C12orf30)G0·425·97×10−8; 1·10 (1·06–1·14)0·59; 1·01 (0·97–1·05)1·92×10−50·60; 1·01 (0·97–1·05)1·69×10−5IS3rs16851055SPSB4G0·816·34×10−7; 1·12 (1·07–1·17)0·20; 1·03 (0·98–1·08)6·23×10−60·25; 1·03 (0·98–1·08)7·76×10−6CS3rs6763538OXNAD1T0·042·89×10−7; 1·47 (1·27–1·69)0·69; 1·04 (0·87–1·24)2·68×10−50·59; 1·05 (0·88–1·25)1·36×10−5LVD11rs7937106ALKBH8C0·165·85×10−8; 1·68 (1·40–2·03)0·66; 1·04 (0·87–1·25)3·93×10−50·65; 1·05 (0·85–1·31)1·42×10−4LVD6rs556621..T0·334·63×10−7; 1·20 (1·12–1·28)0·46; 1·03 (0·96–1·10)5·33×10−50·37; 1·03 (0·96–1·11)2·43×10−5SVD18rs7407640AFG3L2A0·212·20×10−6; 1·23 (1·13–1·34)0·99; 1·00 (0·91–1·10)4·54×10−40·57; 0·97 (0·88–1·07)1·16×10−3SVD2rs13407662..T0·045·18×10−8; 1·95 (1·53–2·48)0·28; 1·16 (0·89–1·51)1·97×10−60·36; 1·14 (0·86–1·53)1·88×10−6FS3rs7432308..T0·151·63×10−6; 1·16 (1·09–1·24)0·15; 0·95 (0·88–1·51)4·80×10−30·37; 0·96 (0·89–1·05)9·13×10−4FS12rs2238151ALDH2T0·661·03×10−6; 1·13 (1·08–1·19)0·26; 1·03 (0·98–1·09)8·62×10−60·22; 1·04 (0·98–1·11)3·98×10−6YS7rs12703165PRKAG2G0·825·63×10−7; 1·20 (1·12–1·29)0·49; 0·98 (0·93–1·04)0·0120·89; 1·00 (0·94–1·06)1·81×10−3YS8rs4875812ARHGEF10G0·551·40×10−6; 1·16 (1·10–1·23)0·87; 1·00 (0·97–1·03)0·0340·94; 1·00 (0·97–1·03)0·024Chr=chromosome. SNP=single nucleotide polymorphism. RA=risk allele. RAF=risk allele frequency. pdiscovery=one-sided p value in discovery cohorts. ORdiscovery=odds ratio in discovery cohorts. preplication,=one-sided p value in replication cohorts. ORreplication=odds ratio in replication cohorts. pcombined=one-sided p value in all cohorts combined. IS=all ischaemic stroke. CS=cardioembolic stroke. LVD=large-vessel disease. SVD=small-vessel disease. FS=female-only stroke. YS=young stroke.