The database is implemented in MySQL [57]. As shown in figure 1, the central table is 'Gene', an up-to-date list of human genes from the NCBI Entrez Gene database. The Gene table is linked to other master tables: The SNP model table contains our stability and profile analysis of SNPs. There is a table of keyterms for each gene, and a table of PubMed abstract IDs for each gene. The KnowledgeNet matrix table contains the pairwise gene-gene interaction strengths, and there is also a disease/candidate gene matrix. Some other tables linked to the Gene table are: the Transcript table (RefSeq mRNAs); the Protein table (RefSeq proteins); the phenotype and disease-tables (NCBI OMIM and human gene mutation database (HGMD)); Mouse knockout table (Bioscience mouse knockout); pathway (KEGG), protein-protein interactions (BIND); and protein function (GO).
