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Chunk #6 — 2. Methods — 2.1 Participants

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Brain metabolite levels in recently sober individuals with alcohol use disorder: Relation to drinking variables and relapse.
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Control and AUD groups were not significantly different with respect to age, blood pressure (systolic or diastolic), body mass index (BMI), or performance on the Mini-Mental State Exam (MMSE)(Folstein et al., 1975) or the National Adult Reading Test (NART) (Nelson, 1982). Based on a quantitative handedness questionnaire (Crovitz and Zener, 1962), 2 control and 3 AUD subjects were left-handed; 2 AUD subjects were ambidextrous. AUD relative to control subjects had higher lifetime alcohol consumption (p<0.0001), elevated heart rate (p=0.017), lower socio-economic status (SES) (Hollingshead, 1975) (p<0.0001), less education (p<0.0001), poorer global assessment of functioning (GAF) scores (p<.0001)(First, 2000), and worse performance on the American-NART (p=0.0184). Five AUD men and 3 AUD women were current smokers; an additional 4 AUD men and 1 AUD woman were past smokers. Out of 20 AUD subjects, 7 met criteria for current anxiety diagnoses (including generalized anxiety (n=1), anxiety disorder not otherwise specified (n=5), or social phobia (n=1)); 5 for major depressive episode (3/5 substance induced); and 5 for past dependence on other drugs of abuse (cocaine (n=1), amphetamine (n=2), methamphetamine (n=2). One of the