It should be noted that these regions of the fronto-limbic circuit involved in dysregulated fear and IU also form networks with structures of the other five neurocircuits to participate in other neurocognitive functions. For example, the amygdala and vmPFC are also involved in reward processing along with regions of the ventral affective circuit [49]. Since altered reward processing is also implicated in OCD (discussed further in the Ventral Affective Circuit section, below), it will be important for future research to investigate how fear and uncertainty-related functional alterations in the fronto-limbic circuit affect reward processing mechanisms in the ventral affective circuit. The interactive nature of these circuits should also be kept in mind when considering neurocircuit-specific treatment strategies for the fronto-limbic circuit, discussed next.
