Despite the general PFC topographic input to the striatum described above, dense terminal fields from the vmPFC, OFC, and dACC show a complex interweaving and convergence, providing an anatomical substrate for modulation between circuits14 (Figure 5). For example, dense projections from the dACC and OFC regions converge extensively at rostral levels. By contrast, there is greater separation of projections between terminals from the vmPFC and the dACC/OFC, particularly at caudal levels. These regions of convergence between the dense terminal fields of the vmPFC, OFC, and dACC provide an anatomical substrate for integration between different reward processing circuits within specific striatal areas and may represent critical “hubs” for integrating reward value, predictability, and salience (Figure 5a).
