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Chunk #35 — DISCUSSION

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Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.
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eGenes (Teslovich et al., 2010; Innocenti et al., 2011). Thus, we expect that comparisons of much larger, better-powered HLC cohorts and liver cohorts would reveal substantially more overlap of eGenes than we observed in the present study. The establishment of iPSC biobanks by efforts such as the NHLBI Next Generation Genetic Association Studies Consortium (http://www.wicell.org/home/stem-cell-lines/collections/collections.cmsx) should make it feasible for investigators to perform future iPSC-based eQTL/ASE studies with thousands of samples.