While large-scale population-based studies, such as the UK Biobank, are valuable in their potential to identify multiple risk loci for easily-collectible phenotypes, such as alcohol consumption, and contribute to the development of well-powered PRS, they may not adequately capture the genetic factors that contribute to problem drinking, which itself is a multi-faceted phenotype. Until there are similarly large-scale GWAS conducted in samples ascertained for problem drinking, the amount of genetic overlap between alcohol consumption and problematic drinking behaviors remains unclear.
