A key finding of our study is that there was a robust down-regulation of GABBR1 in both alcoholics and cocaine addicts compared with controls and in P rats compared with NP rats suggesting that GABBR1 down-regulation could be a predictor for increased risk for addiction. A congruent finding is that NSF, which plays a role in the regulation of GABAB receptor signaling efficacy [32] was also down-regulated in both cocaine addicts and P rats.
