Following quality control, the primary meta-analysis (Worldwide ancestry (WW)) included data on 6695386 common variants across all chromosomes (1−22, X) (minor allele frequency, MAF >0.05; imputation quality score (INFO) >0.60). The secondary GWAS, restricted to individuals defined as being of European (EUR) ancestry, included data on 6632956 common variants that surpassed quality control criteria. Summary Manhattan and PP plots for each analysis are reported in Additional file 1: Figures S2 (WW) and S3 (EUR). We applied a genomewide significance threshold of P ≤ 5 × 10−8. None of the markers investigated exceeded this threshold in the WW meta-analysis. A summary table, containing details of linkage independent associations at P < 10−4 is reported in the Additional file 2 (WW) and Additional file 3 (EUR). Complete summary statistics for these analyses are available at https://www.med.unc.edu/pgc/results-and-downloads.
