Significant interactions with predicted cell-type proportions (BH-FDR < 0.05; Supplementary Table 22)—oligodendrocytes (n = 27), other neurons (n = 7), astrocytes (n = 7) and microglia (n = 2)—were also observed for 41 trans-eQTLs (5.9%). Four eQTLs—all influencing DTX4 and dependent on oligodendrocyte proportion—replicated significantly in the ROSMAP snRNA-seq dataset with the same direction of effect (Supplementary Fig. 30 and Supplementary Table 23).
