Chunk #12 — Results — GWA analysis and extraction of ADME genes

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Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver.

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We used additive linear models in GenABEL34 to detect associations between SNPs and expression traits, and we considered a comprehensive set of available clinical data as covariates (Supplementary Table S1). In total, we identified 1226 significant associations (1179 cis and 47 trans) between 1163 SNPs and 371 different expression traits (Figure 2, Supplementary Table S2).