to pathology. Similarly, at least some cortex samples from autistic brains converge on a common transcriptional profile91. By contrast, various blood disorders have been shown to correlate with extreme values for the major vectors of modules of gene expression92. More research on the relationship between endophenotypes and disease is needed, but most observers would consider it implausible that natural variation in physiology is irrelevant to variation in disease susceptibility, and would maintain that common variants are most likely responsible for continuously distributed physiological variation.
