the observation that these CpGs largely hypomethylated for diagnosis (compared to adult controls) were relatively highly methylated in fetal life (Supplementary Figure 14, ρ= −0.63, p < 10−20), and appeared to further diverge from fetal levels compared to the adult non-psychiatric controls. Thus, the schizophrenia associations at these CpGs strongly reflect DNAm changes related to early developmental events supporting a neurodevelopmental component not only to genetic risk but also to environmental risk of this debilitating disorder.
