Assessment of replication using summary statistics demonstrated no evidence of replication; results are presented in the supplementary data, Table B(i) and (ii) in S2 File. We present comparison of the two genes CCDC42 and BRSK2 with the data for the two different populations, African-American and European-American. In general, the replication samples demonstrated p-values > 0.1 compared to p-values <10−5 in our dataset, for the selected markers. When examining the association status of candidate genes, we did not observe association with variants in the selected candidate genes. The results are presented in the supplementary data; in Table C(i) in S2 File we present the candidate gene list compiled using previously published studies and Table C(ii) in S2 File shows results in our study, highlighting p-values of the most associated SNPs in these genes.
