paperKB
coga / coga-kb
Help
Sign in

Chunk #41 — Methods — eQTL enrichment analyses — Enrichment of variants associated with brain and non-brain complex traits in eQTLs

Source
Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders.
Embedded
yes

Text

GWAS results for attention deficit hyperactivity disorder [31], anorexia nervosa [32], autism spectrum disorder [33], bipolar disorder [34], major depressive disorder [35], neuroticism [26], schizophrenia [36], body mass index [39], coronary artery disease [40], inflammatory bowel disease [41], height [42], and type 2 diabetes [43] were downloaded, and the P values for all variants were reformatted as input to GARFIELD. All 5% FDR eQTLs for eTranscripts were used to define an annotation category. We tested for enrichment in fetal brain eQTLs of variants associated with each trait at multiple significance thresholds (P < 5 × 10− 5, 5 × 10− 6, 5 × 10− 7, 5 × 10− 8). In total, we tested 12 traits and 4 significance thresholds, highlighting enrichments that surpassed the Bonferroni corrected threshold P < 0.001.