brain health outcomes. Furthermore, studies that include richer phenotyping of trauma exposure, other influential adverse childhood experiences, and social determinants of health would better inform the degree to which trauma is associated with normative and atypical aging across the lifespan. Overall, our study increases understanding of the complex associations between childhood trauma, genetics, and brain functioning during the important, yet understudied period of adolescent neurodevelopment, and draws links to psychiatric functioning later in life. Findings may be used to improve clinical understanding of sex differences in the relationship between trauma and APOEε4 and neurophysiology, as well as potentially inform intervention and treatment of childhood trauma to mitigate long-term impacts on mental health and aging.
