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Chunk #20 — RESULTS — ANYDEP and QUANTDEP — Genetic Analysis

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Association of substance dependence phenotypes in the COGA sample.
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Association analyses results are summarized in Figure 2. All association results with p<1.0×10−6 are shown in Table 2. More extensive results are provided in Supplemental Table 1. The QQ plot for ANYDEP revealed inflation of p-values (λ = 1.0608); therefore Genomic Control (GC) p-values were calculated. The lambda for the inflation-corrected p-values = 0.99999, indicating no further inflation. All p-values reported for ANYDEP are GC p-values. There was no evidence to suggest inflation of the association p-values for QUANTDEP (QUANTDEP λ = 1.0095). QQ plots are provided for each phenotype (Supplemental Figure 2).