knockout mice displayed decreased ethanol withdrawal HICs than controls; however, this effect was dependent on background strain of the mice (Mihalek et al. 2001). Interestingly, studies in α6-GABAA receptor knockout mice (which pairs with δ in the cerebellum) did not differ in ethanol withdrawal-related HICs (Homanics et al. 1997). Finally, withdrawal from acute high doses of ethanol has also been used to assess the role of specific GABAA receptor subtypes. For instance, γ2-GABAA receptor transgenic mice did not differ from controls (Wick et al. 2000) in sensitivity to acute withdrawal HICs (Boehm et al. 2004b).
