The second hypothesis tested whether PSI moderated the A, C and E influences on RSI. Here, PSI potentially moderates the extent to which A, C and E influence RSI – the moderation of the A component by PSI represents a latent genetic x measured environment interaction – thus, as shown in Panel B of Figure 1, total additive genetic influences on RSI are modified from A to A+X*PSI, where X represents the extent to which PSI moderates the magnitude of genetic influences on RSI (47–49) – therefore, the statistical significance of X represents (additive) gene x environment interaction.
