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Chunk #14 — 3. Results

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Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.
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Table 3 presents results from family based association tests for each of the 4 predetermined phenotypes. No tests reached statistical significance. Given that genetic heterogeneity could conceivably lead to a dampened signal in our combined sample analyses, the FBAT analyses were also completed within patient families and separately, within control families. For CD, CD symptom count, AUD and AD results were nonsignificant within-patient families (p-values were 0.43, 0.79, 0.10 and 0.70, respectively) and within control families (p-values were >0.99, 0.38, 0.17 and 0.44, respectively).