We used a threshold of genome-wide significance (7.2 × 10−8) derived from a published, genome-wide simulation of common variants in samples of European ancestry4. This threshold is more conservative than the value of 1.6 × 10−7 that would represent a Bonferroni-corrected p=0.05 for the approx. 318,000 markers tested, but is consistent with accepted thresholds for genome-wide significance26. Although we set out to find variants shared in common between BP and MDD, we have considered only BP in other studies16. The results at rs2251219 would remain significant even if multiplied by 2 to account for this.
