The aim of the current study was to combine existing samples to conduct a more powerful GWAS of anorexia nervosa. To further characterize the nature of the illness, we applied linkage disequilibrium score regression (LDSC) (8) to calculate genome-wide common variant heritability ( hSNP2), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and other phenotypes. These include the other major psychiatric disorders with large GWAS, namely schizophrenia, bipolar disorder, major depressive disorder, autism, and attention deficit hyperactivity disorder (ADHD). We then used rg estimates between anorexia nervosa and 159 additional phenotypes (as described below) to characterize the phenome-wide genetic architecture of AN.
