Two children with GTS, OCD, and mental retardation had an insertion of 2p21-23 within 7q35-36, resulting in trisomy of 2p21-23 and disruption of 7q35-36 [80]. The trisomy of 2p21-23 is especially notable, since this region overlaps with the 2p23.2 linkage signal in the TSAICG linkage study as discussed above [59]. Another recent study described the translocation t(7;15)(q35;q26.1) in phenotypically normal individuals [81].
