this can inform the differential diagnoses under consideration. Consider a patient in the current framework who is diagnosed with SCZ and has a family history of BIP. A future diagnostic system might use convergent evidence across different levels of explanation (e.g., genomics, functional imaging, sociocontextual factors) to reconceptualize BIP and SCZ as sharing risk pathways relevant to episodic emotion dysregulation and SCZ as additionally characterized by cognitive deficits. A model where a patient and their family members are diagnosed with episodic dysregulation, and the patient additionally noted to have cognitive deficits, provides more tangible intervention targets with explicitly linked familial risk pathways.
