Chunk #31 — GIRK channels in pain perception and analgesia

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Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.

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GIRK channels have been implicated in pain perception. This notion is based on studies with mice carrying mutations in GIRK channels, and the activation of GIRK channels by endogenous pain modulators such as endorphins, endocannabinoids and analgesic drugs.