al., 2014). These two receptors have different affinities for Crh, with Crhr1 binding Crh at low concentrations and Crhr2 binding only at high concentrations. Crhr1 is activated by acute stress and initiates decreased serotonin release and active coping, while Crhr2 is activated by repeated stress and increases serotonin release and passive coping (Valentino, Lucki et al. 2010). In the DRN of these binge drinking adolescent animals, Crhr1 increased 3 fold and Crhr2 decreased 1.6 fold, which could contribute to decreased serotonin levels in these animals.
