Quanto (57, 58) was used to approximate statistical power given the following assumptions: two-tailed α=1×10−7 (=0.05/500,000), 1,738 cases and 1,802 controls, lifetime morbid risk of MDD of 0.15, and a log additive genetic model. For statistical power of 0.80 (β=0.20), the minimum detectable genotypic relative risks are 1.59, 1.40, and 1.35 for minor allele frequencies of 0.10, 0.25, and 0.40.
