as discovery in this study) and an additional 102,757 individuals selected at random from the entire UK Biobank. From these 102,757 individuals, we initially selected 51,117 samples that had lung function measurements (FEV1 and FVC) meeting ATS/ERS criteria and had covariates age, sex, height, principal components and smoking status recorded. Following further exclusion of individuals with sex mismatches (n=41), individuals of non-European ancestry (based on k-means clustering of principal components 1 and 2 with 4 clusters, n=124) and one individual from each pair of related samples (KING relatedness > 0.088 [2nd degree], n=1,225), a total of 49,727 individuals remained for analysis.
