We note that relapse rates used in the time to relapse analysis are not directly comparable to the relapse rates presented in Figure 2, as the time-dependent information on relapse is via self-report and daily use can not be biochemically verified. Throughout the course of the trial and follow-up period, individuals with the WT genotype and received bupropion had the highest abstinence rates. Those individuals carrying the minor allele and who received buporpion had higher abstinence rates during the trial as compared to placebo, but those rates dropped to those of placebo by 6-month follow-up. A 2-df LRT for the gene and gene-treatment interaction from a Cox regression yielded a P-value of 0.0002.
