The effect of GWAS genetic evidence on approval was considerably reduced and lacked statistical significance in the New Genetic dataset. In reanalyzing the original data, we found the estimated effect of GWAS genetic evidence was highly sensitive to the choice of trait-indication similarity cutoff used to determine whether or not a drug target had a genetic association (S3 Fig). Learning from this analysis, we sought to build a model relating genetic evidence to the probability of drug approval in the full dataset.
