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Chunk #24 — DISCUSSION

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Nominal association with CHRNA4 variants and nicotine dependence.
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Likewise, SNP rs2072658 in the 5′ UTR of CHRNB2 has been associated with the subjective effects reported when subjects were asked to retrospectively recall how nicotine made them feel shortly after taking the drug (Ehringer et al. 2007) and reported subjective responses to cigarettes when smoked in a controlled laboratory setting (Hoft et al. 2011). However, there was no evidence for association with rs2072658 in the current study of ND symptoms.