For the phenotype of MDD, we can exclude combinations of MAF and effect size with 90% power. The exclusionary regions are genotypic relative risks (GRRs) ≥1.16 for MAF 0.30–0.50, ≥1.18 for MAF 0.20–0.25, ≥1.21 for MAF 0.15, ≥1.25 for MAF 0.10 and ≥1.36 for MAF 0.05. The technologies we used for genotyping probably captured the more common variation well, but were progressively less comprehensive at lower MAF. These exclusion GRRs equate to a variance in liability of ~0.5%. Since this study was conceived, we have gained considerable knowledge about the likely effect sizes of variants contributing to common complex disease. Therefore, these exclusion architectures are not unexpected.
