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Chunk #59 — ONLINE METHODS — Special Cases — Perfect genetic correlation but different heritabilities

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Multi-trait analysis of genome-wide association summary statistics using MTAG.
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This case arises when the “traits” are different measures of the same trait, some with more measurement error than others, or when the variance in the trait due to non-genetic factors differs. Here the Ω matrix has only T rather than T(T+1)/2 unique parameters to be estimated.