The GBD 2016 CRA includes 84 risk factors and an associated 481 risk-outcome pairs. In addition to new data and updated methods, we have included five new risks in the GBD 2016 CRA. The study was undertaken for 195 countries and territories and provides estimates of exposure and attributable deaths and disability-adjusted life-years (DALYs) for 1990 through to 2016. We explored how risks change with development, measured by the Socio-demographic Index (SDI), and also decomposed changes in deaths and DALYs into the contributions of population ageing, population growth, trends in risk exposure, and all other factors combined. As with previous iterations of GBD, the GBD 2016 CRA results presented here supersede all previously published GBD CRA estimates.