association with AIDS progression45 and psoriasis46,47. HLA imputation analysis shows the cis-eQTL can be defined in terms of presence of HLA alleles C*0602 and C*1203 (Supplementary Figure 14b,c). Further investigation is required to resolve the role of HLA-C and genetic variation at this locus in terms of disease susceptibility. C*0602 has been strongly implicated in susceptibility to psoriasis48, while current evidence shows that the association with HIV control and progression is more complex, with HLA-B mediated peptide presentation playing a key role49.
