individual to addiction (Anier et al., 2010). Another study determined that animals with a history of maternal separation began self-administering methamphetamine earlier and self-administered a greater quantity of methamphetamine relative to control animals. This paralleled decreased MeCP2 levels in the nucleus accumbens core (Lewis et al., 2013). Collectively, these studies highlight global and gene-specific alterations resulting from maternal separation that could underlie enhanced drug seeking behavior.
